- Tay-Sachs disease, Tay-Sachs, Sachs disease, infantile amaurotic idiocy - a hereditary disorder of lipid metabolism occuring most frequently in individuals of Jewish descent in eastern Europe; accumulation of lipids in nervous tissue results in death in early childhood
--1 is a kind of lipidosis; autosomal recessive disease, autosomal recessive defect; monogenic disorder, monogenic disease