- annoyance, bother, botheration, pain, infliction, pain in the neck, pain in the ass - something or someone that causes trouble; a source of unhappiness; "washing dishes was a nuisance before we got a dish washer"; "a bit of a bother"; "he's not a friend, he's an infliction"
--1 is a kind of negative stimulus
--1 has particulars: nuisance; irritant, thorn; plague