Adjective prickly has 2 senses
  1. bristly, prickly, splenetic, waspish - very irritable; "bristly exchanges between the White House and the press"; "he became prickly and spiteful"; "witty and waspish about his colleagues"
    Antonym: good-natured (indirect, via ill-natured)
  2. barbed, barbellate, briary, briery, bristled, bristly, burred, burry, prickly, setose, setaceous, spiny, thorny - having or covered with protective barbs or quills or spines or thorns or setae etc.; "a horse with a short bristly mane"; "bristly shrubs"; "burred fruits"; "setaceous whiskers"
    Antonym: unarmed (indirect, via armed)
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