Verb wear upon has 1 sense
  1. tire, wear upon, tire out, wear, weary, jade, wear out, outwear, wear down, fag out, fag, fatigue - exhaust or tire through overuse or great strain or stress; "We wore ourselves out on this hike"
    --1 is one way to indispose
    Sample sentences:
    Somebody ----s somebody
    Something ----s somebody
,