Verb act upon has 1 sense
  1. influence, act upon, work - have and exert influence or effect; "The artist's work influenced the young painter"; "She worked on her friends to support the political candidate"
    --1 is one way to affect, impact, bear upon, bear on, touch on, touch
    Sample sentences:
    Somebody ----s something
    Somebody ----s somebody
    Something ----s somebody
    Something ----s something