Adjective despicable has 2 senses
- contemptible, despicable - worthy only of being despised and rejected; "a contemptible lack of courage"; "A little, wretched, despicable creature, a worm, a mere nothing...that has risen up in contempt against the majesty of Heaven and earth"- Jonathan Edwards
Antonym: noble (indirect, via ignoble)
- despicable, ugly, vile, unworthy - morally reprehensible; "would do something as despicable as murder"; "ugly crimes"; "the vile development of slavery appalled them"
Antonym: good (indirect, via evil)