Adjective nettlesome has 2 senses
  1. annoying, bothersome, galling, irritating, nettlesome, pesky, pestering, pestiferous, plaguy, plaguey, teasing, vexatious, vexing - causing irritation or annoyance; "tapping an annoying rhythm on his glass with his fork"; "aircraft noise is particularly bothersome near the airport"; "found it galling to have to ask permission"; "an irritating delay"; "nettlesome paperwork"; "a pesky mosquito"; "swarms of pestering gnats"; "a plaguey newfangled safety catch"; "a teasing and persistent thought annoyed him"; "a vexatious child"; "it is vexing to have to admit you are wrong"
    Antonym: agreeable (indirect, via disagreeable)
  2. cranky, fractious, irritable, nettlesome, peevish, peckish, pettish, petulant, testy, tetchy, techy - easily irritated or annoyed; "an incorrigibly fractious young man"; "not the least nettlesome of his countrymen"
    Antonym: good-natured (indirect, via ill-natured)
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